Our Clinical Research
Welcome to the Clinical Research section at Mildmay Research Centre Uganda (MRCU) where we contribute to both observational and interventional clinical studies to improve health and wellbeing for all. MRCU has a conducive environment to host the clinical studies given the collaborative work with the autonomous Centre of Excellence, the Mildmay Hospital Uganda (MHUg), a general Hospital with over 16,000 People Living with HIV (PLHIV) in its care. The MHUg hospital as research laboratory that is ISO 15189 South African National Accreditation System (SANAS) accredited. The laboratory serves as a backup to the Central Public Health Laboratory/Ministry of Health (MoH) Uganda for viral load testing, COVID-19 testing and HIV DNA PCR testing. The clients at the hospital contribute to generation of evidence by offering to serve as study participants.
About Us
The clinical studies at MRCU range from studies targeting mental health, sexual and reproductive health and improvement of therapeutics for HIV through clinical trials.
Researchers
We have a multi-disciplinary team of researchers including Mental Health Experts, Clinical Trial Experts and Medical Personnel
- Dr. Jackson Mukonzo
- Dr. Helen Ndagije
- Dr. Yvonne Karamagi
- Dr. Barbara Mukasa
- Dr. Ronald Mulebeke
- Prof. Glenn Wagner
Collaborating Organizations
At MRCU, we build synergy through collaborative research, with local and international organizations.
- Makerere University School of Medicine
- National Drug Authority, Uganda
- The RAND Corporation
- Mildmay Hospital Uganda
Clinical Trials
There is an ongoing clinical trial in line with improvement of therapeutics for HIV care:
Study Title: Safety and efficacy DTG and EFV400 for pregnant and breast-feeding women: a randomized non-inferiority clinical trial (PREGART). The study aims to provide evidence-based recommendation for safe and effective first line ART regimens for PMTCT and treatment of HIV infected pregnant and breast-feeding women living in resource-limited settings.
Principal Investigator (PI): Dr. J Mukonzo
Funder: European and Developing Countries Clinical Trial Partnership (EDCTP)
Collaborating organizations: Makerere University School of Medicine.
Past Observational Clinical studies
MU-CT-002-1221 (Kalebu, PI) 03/01/2022 – 02/28/2024
EDCTP: Use of Point of Care HIV Viral Load Monitoring to improve Viral Load Suppression among Children, Adolescents Living with HIV in East Africa. The study aim is to evaluate feasibility, acceptability, and effectiveness of using PoC HIV VL monitoring to improve viral load suppression rates among children and adolescents living with HIV in East Africa.
R01MH115830 (G. Wagner, PI) 08/15/2018-05/08/2023
NIH/NIMH: Depression Care to Improve Adherence to PMTCT Care Continuum & Pregnancy Outcomes. This study aims at generating evidence for providing a model for integrating depression care into Antenatal clinics and promoting optimal adherence to the PMTCT care continuum and maternal and child health outcomes.
MU-CT-001-0521 (Ndagije/Mukasa, PI) 10/02/2020 – 09/30/2021
Uganda National Drug Authority (NDA): Evaluating the Glycemic Effects of Dolutegravir (DTG) among Patients Receiving Dolutegravir Based Regimens at Mildmay Uganda ART sites. The study aims at studying the incidence of hyperglycemia among patients receiving DTG based regimen and the association between previous NRTI or NRTtI exposure at Mildmay Uganda supported sites.